Biochem/physiol Actions Spiramycin is a 16membered ring macrolide antibiotic from Streptomyces ambofaciens It inhibits bacterial protein synthesis at the level of peptidytRNA dissociation from ribosomes It is mainly used against Grampositive bacteriaSpiramycin führt zu einer verminderten Oozystenausscheidung und zu einer Verbesserung der klinischen Symptome Es kann jedoch keine Heilung erreicht werden (Graczyk 1996a) Huhn, Trute, Fasan & Wachtel Spiramycin intramuskulär Sinusitis25 100 mg/kg während 2 7 e (Kroker 1999b) oral Mykoplasma gallisepticum100 0 mg pro Tier einmalig (Arzey 1992a) subkutanBuy high quality Spiramycin Adipate from toronto research chemicals Inc
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Spiramycin structure and chemical name-Spiramycin I contains total 136 bond(s);Spiramycin also induces a decrease in tritiated uridine (3HUdR) uptake, which suggests that Spiramycin interferes with an early event in the cell cycle 4 Spiramycin and, to a lesser extent, erythromycin increases total IL6 production without affecting IL1 alpha, IL1 beta, or tumor necrosis factor alpha production in human monocytes stimulated with lipopolysaccharide
Figure 2 From Genome Mining Of Streptomyces Ambofaciens Semantic Scholar
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards The RCSB PDB also provides a variety of tools and resources Users can perform simple and advanced searches based on annotations relating to sequence, structure and function These molecules are visualized, downloaded, and analyzed by users who range fromSpiramycin wird von Streptomyces ambofaciens synthetisiert und ist ein Makrolid mit einem 16gliedrigen Lactonring ( Kroker 1999b;Spiramycin Specification The Spiramycin, with the CAS registry number , is also known as Foromacidin It belongs to the product categories of Miscellaneous Natural Products;
Spiramycin I Molecular Formula C 43 H 74 N 2 O 14;Contact sites between protein and rRNA in 30S and 50S ribosomal subunits of Escherichia coli and Bacillus stearothermophilus were investigated at the molecular level using UV and 2iminothiolane as crosslinkers Thirteen ribosomal proteins (S3, S4, S7, S14, S17, L2, L4, L6, L14, L27, L28, L29, and L36) from these organisms were crosslinked in direct contact with the RNAs, and thePLQDGTZICFBBSODPUAUXBSSAN Spiramycin adipate Similar structures search, synonyms, formulas, resource links, and other chemical information
TIANFU CHEM Spiramycin Suppliers,provide TIANFU CHEM Spiramycin product and the products related with China (Mainland) TIANFU CHEM Spiramycin Henan Tianfu Chemical Co, Ltd China (Mainland) Welcome to LookChemcom Sign InJoin Free Home;Search Substances SPIRAMYCIN I 033ECH6IFG Possibly Marketed Outside US Source CanadaSPIRAMYCIN Source URLSpiramycin U contains total 133 bond(s);
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Monoisotopic mass Da;Spiramycin is a macrolide originally discovered as product of Streptomyces ambofaciens, with antibacterial and antiparasitic activities Although the specific mechanism of action has not been characterized, spiramycin likely inhibits protein synthesis by binding to the 50S subunit of the bacterial ribosomeChemical structure macrolide Application Spiramycin is a macrolide antibiotic that is commonly used to treat infections of soft tissues It has been used to treat bronchopulmonary infections in adults and has been used to study septicemia in mice Biochem/physiol Actions Spiramycin is a 16membered ring macrolide antibiotic from Streptomyces ambofaciens It inhibits bacterial
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Spiramycin (C 43 H 74 N 2 O 14, M r = 8431 g/mol) wird aus bestimmten Stämmen von Streptomyces ambofaciens gewonnen oder nach anderen Verfahren hergestellt Die Hauptkomponente ist Spiramycin I Spiramycin II und II sind ebenfalls enthalten Spiramycin ist ein weisses bis schwach gelbliches Pulver, das in Wasser schwer löslich ist Wirkungen SpiramycinSpiramycin adipate C49H84N2O18 CID structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and moreCrystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15membered macrolide, azithromycin, show that they bind in the polypeptide exit tunnel adjacent to the peptidyl transferase center Their location suggests that they inhibit protein synthesis by blocking the
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Innate Adaptive And Cell Autonomous Immunity Against Toxoplasma Gondii Infection Experimental Molecular Medicine
Das Antibiotikum Spiromycin besitzt die chemische Summenformel C 43 H 74 N 2 O 14 Bei Zimmertemperatur liegt die Substanz als festes, kristallines Pulver vor In dieser Form besitzt einen leicht hygroskopischen Charakter, d h es zieht Wasser aus der Luft an In Wasser ist der Wirkstoff nur schwach löslichMolecular structure The molecular structure is based on structures generated from information available in ECHA's databases If generated, an InChI string will also be generated and made available for searching This information is only displayed if the substance is welldefined, its identity is not claimed confidential and there is sufficient information available in ECHA's databases for ECHA's algorithms to generate a molecular structureMacrolides (Antibiotics for Research and Experimental Use);
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Spiramycin had been scientifically assessed again in November 1994 by the members of JECFA Spiramycin is a macrolide antibiotic used for the treatment and control of a number of bacterial and mycoplasmal infections in animals Spiramycin adipate and embonate were of low acute toxicity in the laboratory animals after oral orCocrystal Structure of Spiramycin bound to the 50S Ribosomal Subunit of Haloarcula marismortui Help Select a different viewer Citation Images created using Mol* should cite the PDB ID, the corresponding structure publication, Mol* (D Sehnal, S Bittrich, M Deshpande, R Svobodová, K Berka, V Bazgier, S Velankar, SK Burley, J Koča, AS Rose (21) Mol*Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect Spiramycin is composed of a 16member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached Mechanism of Action & Protocol
Macrolides Rapidly Inhibit Red Blood Cell Invasion By The Human Malaria Parasite Plasmodium Falciparum Bmc Biology Full Text
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An antibiotic used for the treatment and control of a number of bacterial and mycoplasmal infections in animals and also used as a growth promotor Availability status Introduction & key dates 00, Europe Examples of species treated Poultry, Sheep, Cattle, Pigs, Cats, Dogs Chemical structure IsomerismStructure activity relationships of spiramycins are discussed Introduction Spiramycin (PinnertSindico et al, 1955) is a complex of 16membered macrolide antibiotics active against Grampositive bacteria, mycoplasmas and toxoplasmas Its acetyl derivative in addition to spiramycin is used clinically Spiramycin contains threeView All Manufacturers & Suppliers of Spiramycin API with Drug Master Files (DMF), CEP/COS, Japanese DMFs, Written Confirmation (WC) details listed on PharmaCompasscom
Spiramycin I D3 9 O 2r 5s 6r 5 Dimethylamino Tetrahydro 6 Methyl 2h Pyran 2 Yl Leucomycin V D3 Foromacidin A D3 Spiramycin A D3 C H D N O Trc
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Spiramycin, a widely used veterinary macrolide antibiotic, was found at traceable levels (nanograms per litre range) in Po River water (NItaly) The aqueous environmental fate of this antibiotic compound was studied through drug decomposition, the identification of the main and secondary transformation products (TPs), assessment of mineralisation and the investigation Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15membered macrolide, azithromycin, show that they bind in the polypeptide exit tunnel adjacent to the peptidyl transferase center Their location suggests that they inhibit protein synthesis by62 nonH bond(s), 4 multiple bond(s), 11 rotatable bond(s), 4 double bond(s), 3 sixmembered ring(s), 1 ester(s) (aliphatic), 1 aldehyde(s) (aliphatic), 2 tertiary amine(s) (aliphatic), 4 hydroxyl group(s), 3 secondary alcohol(s), 1 tertiary alcohol(s) and 7 ether(s) (aliphatic) Learn more about Spiramycin I chemical structure at MolInstincts
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The lack of aromaticity in the molecular structure of spiramycin did not encourage the formation of a complex with SnO 2 Pal In addition, cassiterite crystals deposited onto the palygorskite surface may have reduced the access to adsorption sites 3242 Metronidazole Metronidazole was largely retained by SnO 2 Pal (Fig 7B) The experimental data were properly Spiramycin ist ein natürliches Makrolid und besitzt einen 16gliedrigen Laktonring Der Wirkstoff ist ein Gemisch aus den drei Wirkstoffen Spiramycin A, B und C Der Wirkung kommt durch die Hemmung der Proteinbiosynthese durch Bindung an die 50sUntereinheit des bakteriellen Ribosoms zustande Demnach wirkt Spiramycin bakteriostatischSpiramycin I ChEBI ID CHEBI Definition A macrolide antibiotic produced by various Streptomyces species that is used to treat toxoplasmosis and various other infections of soft tissues Stars This entity has been manually annotated by the ChEBI Team Secondary ChEBI IDs
Significant Reduction Of Brain Cysts Caused By Toxoplasma Gondii After Treatment With Spiramycin Coadministered With Metronidazole In A Mouse Model Of Chronic Toxoplasmosis Abstract Europe Pmc
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Antibiotics for Research and Experimental Use;Spiramycin was effective against a number of such strains in vivo, but erythromycin had little effect against these infections Investigation into the distribution of the antibiotics in the serum and tissues of mice showed that spiramycin was maintained in tissues (lung, liver, kidney, spleen and heart) at higher concentrations and for a longer period than erythromycin, although erythromycin1KD1 Cocrystal Structure Of Spiramycin Bound To The 50s Ribosomal Subunit Of Haloarcula Marismortui PDB ID 1KD1 Download MMDB ID PDB Deposition Date Updated in MMDB 07/10 Experimental Method xray diffraction Resolution 3 Å Source Organism Haloarcula marismortui Similar Structures VAST Download sequence data Biological Unit for
Efficient And Simple Hplc Method For Spiramycin Determination In Urine Samples And In Pharmaceutical Tablets Mahmoudi 18 Separation Science Plus Wiley Online Library
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Average mass Da;My LookChem Message Products;SummarySince the introduction of spiramycin, thousands of patients have been treated with the drug and few have developed severe adverse reactions Gastrointestinal disorders were usually mild and transient, and allergic reactions were quite uncommon Liver injury was described only once and drug interactions have not been reported The safety profile of this 16membered lactone
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Since the introduction of spiramycin, thousands of patients have been treated with the drug and few have developed severe adverse reactions Gastrointestinal disorders were usually mild and transient, and allergic reactions were quite uncommon Liver injury was described only once and drug interactions have not been reported The safety profile of this 16membered lactone ring macrolide derivative may reflect its chemical structureSanders 1994a ) Neospiramycin ist ein Demycarosilderivat von Spiramycin ( Sanders 1994a ) Es kann keinerlei Haftung für Ansprüche übernommen werden, die aus dieser Webseite erwachsen könnten4019 mass spectra in 6 spectral trees are available online for the compound Spiramycin Last modification occurred on PM mzCloud ‒ Free
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We are Spiramycin CAS suppliers and specialize ,,, etcCHEBI spiramycin II A macrolide antibiotic produced by various Streptomyces species This entity has been manually annotated by the ChEBI Team No supplier information found for this compound A molecular entity capable of accepting a hydron from a donor (Br o nsted acid) A drug used to treat or prevent bacterial infectionsA macrolide antibiotic produced by Streptomyces ambofaciens The drug is effective against grampositive aerobic pathogens, N gonorrhoeae, and staphylococci It is used to treat infections
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Spiramycin ist ein Makrolidantibiotikum Es wirkt gegen verschiedene Bakterienarten und kann auch bei Toxoplasmose eingesetzt werden Wirkung Spiramycin bindet an die 50SUntereinheit von Prokaryotischen RibosomenDer Mechanismus beobachteter Resistenzen ist noch nicht vollständig aufgeklärt und kann je nach Organismus unterschiedlich sein Definition62 nonH bond(s), 4 multiple bond(s), 10 rotatable bond(s), 4 double bond(s), 3 sixmembered ring(s), 1 ester(s) (aliphatic), 1 aldehyde(s) (aliphatic), 1 tertiary amine(s) (aliphatic), 6 hydroxyl group(s), 4 secondary alcohol(s), 2 tertiary alcohol(s) and 7 ether(s) (aliphatic) Learn more about Spiramycin U chemical structure at MolInstincts
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50 5 Spiramycin I Contains 6 Spiramycin Iii 9 O 2r 5s 6r 5 Dimethylamino Tetrahydro 6 Methyl 2h Pyran 2 Yl Leucomycin V Foromacidin A Spiramycin A C H N O Trc
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